Page last updated 2/25/2026.
On this page:
- Cancer Cluster Criteria
- Local Situation
- Reporting
- Resources
A group of cancers cases is a cancer cluster when all criteria are met.
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A greater than expected number of cancer cases:
- When the observed number of cases is higher than what would typically be observed in a similar setting (in a group with similar population, age, race, or gender).
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Of the same (etiologically) related cancer cases:
- Cancer cases are the same type, are within a family of tumors, or have the same cause/exposure.
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Occur within a group of people:
- The population the cancers are affecting is defined by demographic factors, such as race/ethnicity, age, and gender.
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In a defined geographic area:
- Boundaries of the area where cancer cases occur need to be defined carefully. Moving boundaries (e.g. making an area larger or smaller) might make it look more or less likely that a cancer cluster exists.
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Over a specific period of time:
- The number of cancer cases needs to be looked at over a specific time period when determining if there are more than the expected number of cases.
Until all criteria are met, the group of cancer cases is often called a suspect cancer cluster. The definition of a cancer cluster does not include anything about the cancers all having a common cause.
Cancer (CCR Title 17 §2593) is a reportable disease.
- Cancer Prevention and Control
- Disease Reporting Requirements for Health Care Providers
- The California Cancer Registry (CCR) is a statewide, population-based cancer surveillance system. The CCR collects information about almost all cancers diagnosed in California.
Local
- Disease Reporting Requirements for Health Care Providers
- County Department of Environmental Health
- Air Pollution and Control District
State
- California Department of Public Health Environmental Health Investigations Branch
- California Cancer Registry (CCR)
- California Department of Toxic Substances Control EnviroStor
National
- Centers for Disease Control and Prevention (CDC) About Unusual Patterns of Cancer
- National Institutes of Health (NIH) National Cancer Institute Cancer Clusters
Call the Epidemiology Unit at (619) 692-8499, or send an e-mail, for more information.



