• Clinical Features of Mpox (CDC)
  • Clinical Overview of Clade I and Clade II Mpox  
• Mpox Clinical Recognition and Testing Overview and Quicksheet (California Prevention Training Center)

Testing

• Guidelines for Collecting and Handling Specimens for Mpox Testing (CDC)​ 
• Testing for Suspected Clade I Mpox (CDPH)

Clinical Considerations for Special Populations

• Children and Adolescents (CDC)
• People Who are Pregnant or Breastfeeding (CDC) 
• People Who are Immunocompromised, including HIV (CDC)

Prevention and Waste Management

• Infection Prevention and Control of Mpox in Healthcare Settings (CDC) 
• Cal/OSHA: Protecting Workers from Mpox for Employers and Workers Covered by the Aerosol Transmissible Disease Standard (Title 8 Section 5199)
• Mpox ​​Virus Medical Waste Management​ Guidelines (CDPH) 
• Preventing Occupational Mpox Transmission in Outpatient Clinic (California Prevention Training Center) 

Treatment

• Caring for Patients with Mpox​​ (CDC) 
• Clinical Considerations for Pain Management (CDC) 
• Isolation and Infection Control at Home (CDC)
• Mpox Treatment with Tecovirimat (TPOXX) and Other Therapeutics: Updated Guidance for Health Care Providers (CDPH) 
• Interim Clinical Considerations for Management of Ocular <pox (CDC) 
• Supportive Care Guidance​ (CDPH) 

Educational Materials

• For Clinicians: What to do if you suspect mpox
• For Patients: What to do if you are sick with mpox | Spanish

Vaccine Information

JYNNEOS remains recommended for anyone who may be at risk for mpox exposure​ or who requests it. As of June 2024, JYNNEOS vaccine is commercially available for ordering, similar to other FDA-approved vaccines.  

• Mpox Vaccination Resources (CDPH EZIZ)

Reporting

• Immediately report probable, suspected, and confirmed clade I MPXV cases to the County of San Diego Health and Human Services Agency.
• Submit a Confidential Morbidity Report by fax to (619) 692-8451 or secure email to phs-hshb-stdreporting-fax.hhsa@sdcounty.ca.gov. 

California Health Alert Network San Diego (CAHAN) Alerts

• Community Spread of Clade I Mpox in Southern California (October 21, 2025)
• First Case of Clade I Mpox Diagnosed in California and the United States in Returning Traveler (November 22, 2024)
• Mpox Human-to-Human Transmission and Geographical Spread in Africa (August 15, 2024)
• Clade I Mpox Virus in Travelers to the Democratic Republic of the Congo (December 15, 2023)
• Local Increase in Mpox Cases (October 25, 2023)
• Potential Risk for Mpox Resurgence (May 16, 2023)
• Identification, Laboratory Testing, Management and Treatment, and Vaccination for Mpox Virus Infection in California (April 10, 2023)
• Mpox Treatment with Tecovirimat and Supportive Measures (September 19, 2022)
• Mpox Vaccination with Jynneos (August 16, 2022)
• Mpox, Testing at Commercial Laboratories (July 15, 2022)
• Meningococcal Infections and mpox in Men who Have Sex with Men (June 10, 2022).
• Mpox (May 23, 2022).
• County News Center