Perinatal Hepatitis B Prevention Program

The County of San Diego Perinatal Hepatitis B Prevention Program provides case management and support to local mothers and medical providers with the goal of preventing perinatal, or mother-to-baby, transmission of hepatitis B virus infection.

Hepatitis B is a viral liver disease that can be spread via:

  • sexual transmission
  • injection drug use
  • blood borne/body fluid exposures
  • mother to baby at birth

Individuals that are diagnosed with Hepatitis B may be asymptomatic or can experience symptoms such as fatigue, fever, yellow skin and eyes (jaundice), abdominal pain, and change in color of stool.

When an infant is born to a Hepatitis B positive mother, 70-95% of those infants will develop a chronic infection if they do not receive the appropriate vaccines at birth and early childhood. Chronic Hepatitis B can cause many health issues including liver cancer, liver failure, and death.

Program Objectives and Services

  • Provide case management for Hepatitis B positive pregnant women and their infants. 
  • Educate medical providers, birth hospitals, and Hepatitis B infected pregnant women and their close contacts.
  • Coordinate with birth hospitals to promote implementation of national perinatal Hepatitis B prevention recommendations. 
  • Screen and vaccinate at-risk close contacts. 
  • Provide technical assistance, consultation, resources, and coordination of services. 

About the Perinatal Hepatitis B Prevention Program

Centers for Disease Control and Prevention (CDC) “funds 64 jurisdictions to identify pregnant persons infected with Hepatitis B virus and to manage their infants to improve receipt of post-exposure prophylaxis, hepatitis B vaccine series completion, and post-vaccination serologic testing." For outcome data and additional information, please click here.

The following jurisdictions participate in the program

  • All 50 US States
  • District of Columbia
  • 5 cities - Chicago, Houston, New York City, Philadelphia, and San Antonio
  • 5 territories - American Samoa, Guam, N. Mariana Islands, Puerto Rico, U.S. Virgin Islands

The California Perinatal Hepatitis B Prevention Program (CA PHBPP) is managed by CDPH. The program was established in 1991 to provide resources and technical support to local health departments (LHD) for perinatal hepatitis B prevention and to provide surveillance for perinatal hepatitis B cases. In California, all 58 counties and three city public health departments are enrolled in the program.

If you have any questions, please do not hesitate to contact us at 866-358-2966 and select 'option 5' to speak to a public health nurse or email us at